Chemical Analytics and Metabolism
Heikkinen EM, Auriola S, Ranta VP, Demarais NJ, Grey AC, Del Amo EM, Toropainen E, Vellonen KS, Urtti A and Ruponen M. Distribution of Small Molecular Weight Drugs into the Porcine Lens: Studies on Imaging Mass Spectrometry, Partition Coefficients, and Implications in Ocular Pharmacokinetics. Mol Pharm. 2019 Sep 3;16(9):3968-3976. doi: 10.1021/acs.molpharmaceut.9b00585.
Bhattacharya M, Sarkhel S, Peltoniemi J, Broadbridge R, Tuomainen M, Auriola S, Urtti A. Differentially cleaving peptides as a strategy for controlled drug release in human retinal pigment epithelial cells. J Control Release. 2017 Apr 10;251:37-48. doi: 10.1016/j.jconrel.2017.02.013.
Ramsay E, Ruponen M, Picardat T, Tengvall U, Tuomainen M, Auriola S, Toropainen E, Urtti A, Del Amo EM. Impact of Chemical Structure on Conjunctival Drug Permeability: Adopting Porcine Conjunctiva and Cassette Dosing for Construction of In Silico Model. J Pharm Sci. 2017 Sep;106(9):2463-2471. doi: 10.1016/j.xphs.2017.04.061.
Permeation and Binding Studies
Ramsay E, Del Amo EM, Toropainen E, Tengvall-Unadike U, Ranta VP, Urtti A and Ruponen M. Corneal and conjunctival drug permeability: Systematic comparison and pharmacokinetic impact in the eye. Eur J Pharm Sci. 2018 Jul 1;119:83-89. doi: 10.1016/j.ejps.2018.03.034.
Jakubiak P, Reutlinger M, Mattei P, Schuler F, Urtti A, Alvarez-Sánchez R. Understanding Molecular Drivers of Melanin Binding To Support Rational Design of Small Molecule Ophthalmic Drugs. J Med Chem. 2018 Nov 21;61(22):10106-10115. doi:10.1021/acs.jmedchem.8b01281.
Pelkonen L, Tengvall-Unadike U, Ruponen M, Kidron H, Del Amo EM, Reinisalo M and Urtti A. Melanin binding study of clinical drugs with cassette dosing and rapid equilibrium dialysis inserts. Eur J Pharm Sci. 2017 Nov 15;109:162-168. doi: 10.1016/j.ejps.2017.07.027.
Drug Delivery Systems
Lajunen T, Nurmi R, Kontturi L, Viitala L, Yliperttula M, Murtomaki L and Urtti A. Light activated liposomes: Functionality and prospects in ocular drug delivery. J Control Release. 2016 Dec 28;244(Pt B):157-166. doi: 10.1016/j.jconrel.2016.08.024.
Subrizi A, Del Amo EM, Korzhikov-Vlakh V, Tennikova T, Ruponen M and Urtti A. Design principles of ocular drug delivery systems: importance of drug payload, release rate, and material properties. Drug Discov Today. 2019 Aug;24(8):1446-1457. doi: 10.1016/j.drudis.2019.02.001.
Pharmacokinetics and Pharmacodynamics
Del Amo EM, Rimpelä AK, Heikkinen E, Kari OK, Ramsay E, Lajunen T, Schmitt M, Pelkonen L, Bhattacharya M, Richardson D, Subrizi A, Turunen T,Reinisalo M,Itkonen J, Toropainen E, Casteleijn M, Kidron H, Antopolsky M, Vellonen KS,Ruponen M, Urtti A. Pharmacokinetic aspects of retinal drug delivery. Prog Retin Eye Res. 2017 Mar;57:134-185. doi: 10.1016/j.preteyeres.2016.12.001. Epub 2016 Dec 24. Review. PubMed PMID: 28028001.
Preclinical Disease Models
Hellinen L, Pirskanen L, Tengvall-Unadike U, Urtti A and Reinisalo M. Retinal Pigment Epithelial Cell Line with Fast Differentiation and Improved Barrier Properties. Pharmaceutics. 2019 Aug 13;11(8). pii: pharmaceutics11080412. doi: 10.3390/pharmaceutics11080412.
Felszeghy S, Viiri J, Paterno JJ, Hyttinen JMT, Koskela A, Chen M, Leinonen H, Tanila H, Kivinen N, Koistinen A, Toropainen E, Amadio M, Smedowski A, Reinisalo M, Winiarczyk M, Mackiewicz J, Mutikainen M, Ruotsalainen AK, Kettunen M, Jokivarsi K, Sinha D, Kinnunen K, Petrovski G, Blasiak J, Bjørkøy G, Koskelainen A, Skottman H, Urtti A, Salminen A, Kannan R, Ferrington DA, Xu H, Levonen AL, Tavi P, Kauppinen A, Kaarniranta K. Loss of NRF-2 and PGC-1α genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration. Redox Biol. 2019 Jan;20:1-12. doi: 10.1016/j.redox.2018.09.011.
Ryhänen T, Hyttinen JM, Kopitz J, Rilla K, Kuusisto E, Mannermaa E, Viiri J, Holmberg CI, Immonen I, Meri S, Parkkinen J, Eskelinen EL, Uusitalo H, Salminen A, Kaarniranta K. Crosstalk between Hsp70 molecular chaperone, lysosomes and proteasomes in autophagy-mediated proteolysis in human retinal pigment epithelial cells. J Cell Mol Med. 2009 Sep;13(9B):3616-31. doi: 10.1111/j.1582-4934.2008.00577.
Clinical trials
Ferrington DA, Sinha D, Kaarniranta K. Defects in retinal pigment epithelial cell proteolysis and the pathology associated with age-related macular degeneration. Prog Retin Eye Res. 2016 Mar;51:69-89. doi:10.1016/j.preteyeres.2015.09.002. Epub 2015 Sep 4. Review. PubMed PMID: 26344735; PubMed Central PMCID: PMC4769684.
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